INVESTIGATING THE POTENTIAL OF SINGLE-SHOT CO-AMOXICLAV PROPHYLAXIS FOR PREVENTING SURGICAL SITE INFECTIONS IN A TERTIARY CARE HOSPITAL IN PESHAWAR, PAKISTAN
DOI:
https://doi.org/10.69723/njms.03.03.0404Keywords:
Surgical Site Infections, Antibiotic Prophylaxis, Co-Amoxiclav, Surgical Procedures, Patient SafetyAbstract
BACKGROUND: Patients undergoing surgery are at a significant risk of developing surgical site infections (SSIs), which can increase rates of morbidity, mortality, and medical costs. There is a chance that using antibiotics prophylactically for prophylaxis will lower SSIs.
OBJECTIVE: To investigate the potential of a single shot of co-amoxiclav as a preventive measure for preventing surgical site infections.
METHODOLOGY: A retrospective cohort analysis was conducted between 2021 and 2023 at Northwest General Hospital and Research Centre, Peshawar. Examining 1190 patient data, general surgical procedures and single-shot co-amoxiclav prevention were the main topics of interest. Distributions by age, gender, surgical procedure types, and SSIs were all included in the data analysis.
RESULTS: The participants' mean age was 36.22 years, and there were more women (596/1190) than males in every age group. SSIs noted after a single injection were 18/1190 superficial SSIs (1.51%), 7/1190 deep wound infections (0.59%), and 5/1190 deep body cavity infections (0.42%) out of 1190 patients, the overall infection rate was very low, calculated to be 2.52%.
CONCLUSION: The overall infection rate was as low as 2.52% with single-shot co-amoxiclav prophylaxis, highlighting its potential benefit as prevention of SSI.
KEYWORDS: Surgical Site Infections, Antibiotic Prophylaxis, Co-Amoxiclav, Surgical Procedures, Patient Safety.
References
Najjar PA, Smink DS. Prophylactic antibiotics and prevention of surgical site infections. Surg Clin North Am. 2015 Apr;95(2):269-83. https://doi.org/10.1016/j.suc.2014.11.006. Epub 2015 Jan 10.
Bucataru A, Balasoiu M, Ghenea AE, Zlatian OM, Vulcanescu DD, Horhat FG, et al. Factors Contributing to Surgical Site Infections: A Comprehensive Systematic Review of Etiology and Risk Factors. Clinics and Practice. 2024 Feb 1;14(1):52-68. https://doi.org/10.3390/clinpract14010006
Seidelman J, Anderson DJ. Surgical site infections. Infectious Disease Clinics. 2021 Dec 1;35(4):901-29. https://doi.org/10.1016/j.idc.2021.07.006
Cohen NS, Bock JM, May AK. Sepsis and postoperative surgical site infections. J Surg. 2023;174(2):403-5. https://doi.org/10.1016/j.surg.2023.01.006
Amin Yavari S, Castenmiller SM, van Strijp JA, Croes M. Combating implant infections: shifting focus from bacteria to host. Advanced Materials. 2020 Oct;32(43):2002962. https://doi.org/10.1002/adma.202002962
Ullah K, Dogar AW, Jan Z, Bilal H, Tahir MJ, Hamza A, et al. Role of antibiotic prophylaxis on surgical site infection prevention in a low-risk population undergoing laparoscopic cholecystectomy: A randomized controlled study. Ann Med Surg (Lond). 2022 Jun 1;78:103804. https://doi.org/10.1016/j.amsu.2022.103804
Dhole S, Mahakalkar C, Kshirsagar S, Bhargava A. Antibiotic prophylaxis in surgery: current insights and future directions for surgical site infection prevention. Clinics. 2023;15(10). https://doi.org/10.7759/cureus.47858
Evans J, Hannoodee M, Wittler M. Amoxicillin Clavulanate. PubMed. Treasure Island (FL): StatPearls Publishing; 2020. https://doi.org/10.1080/1120009X.2022.2051128
Knight M, Chiocchia V, Partlett C, Rivero-Arias O, Hua X, Bowler U, et al. Intravenous co-amoxiclav to prevent infection after operative vaginal delivery: the Anode RCT. PubMed. NIHR Journals Library; 2019. https://doi.org/10.3310/hta23540
Gazal G, Al-Samadani KH, Alsaidalani HM, Karbouji GA, Alharbi AM. A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial. Int J Environ Res Public Health. 2022 Mar 31;19(7):4178. https://doi.org/10.3390/ijerph19074178
Knight M, Chiocchia V, Partlett C, Rivero-Arias O, Hua X, Bowler U, Gray J, et al. Intravenous co-amoxiclav to prevent infection after operative vaginal delivery: the ANODE RCT. Health Technol Assess. 2019 Oct;23(54):1. https://doi.org/10.3310/hta23540
Baertl S, Walter N, Engelstaedter U, Ehrenschwender M, Hitzenbichler F, Alt V, Rupp M. What is the most effective empirical antibiotic treatment for early, delayed, and late fracture-related infections? Antibiotics (Basel). 2022 Feb 22;11(3):287. https://doi.org/10.3390/antibiotics11030287
Alshoubaki O, Al Darabaa Z, Odat O, Qubbaj A, Alhyari RA, Alshare S, et al. Antibiotic Prophylaxis and Treatment in Early Cardiac Implantable Electronic Devices Infection. 2021 Feb 1;75(1):56-6. https://doi.org/10.5455/medarh.2021.75.56-60
Liabsuetrakul T, Choobun T, Peeyananjarassri K, Islam QM. Antibiotic prophylaxis for operative vaginal delivery. Cochrane Database Syst Rev. 2020 Mar 26. https://doi.org/10.1002/14651858.CD004455.pub5
Stallard S, Savioli F, McConnachie A, Norrie J, Dudman K, Morrow ES, et al. Antibiotic prophylaxis in breast cancer surgery (PAUS trial): randomised clinical double-blind parallel-group multicentre superiority trial. Br J Surg. 2022 Aug 6;109(12):1224-31. https://doi.org/10.1093/bjs/znac280
Ahmed Z, Uwechue R, Chandak P, van Dellen D, Barwell J, Heap S, et al. Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR). Ann Surg. 2019 Oct 25;272(1):65-71. https://doi.org/10.1097/SLA.0000000000003666
Menon RK, Gopinath D, Li KY, Leung YY, Botelho MG. Does the use of amoxicillin/amoxicillin–clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. Int J Oral Maxillofac Surg. 2019 Feb;48(2):263-73. https://doi.org/10.1016/j.ijom.2018.08.002
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