COMPARATIVE STUDY OF THE IMPACT OF ROSUVASTATIN AND FERULIC ACID ON LIPID HOMEOSTASIS AND ATHEROSCLEROTIC INDEX: AN EXPERIMENTAL STUDY
DOI:
https://doi.org/10.69723/njms.03.03.0418Keywords:
Ferulic Acid, Lipid homeostasis, Atherosclerotic indexAbstract
BACKGROUND: Ferulic acid, a phenol with potent antioxidant properties, reduces lipid levels such as triglycerides, low-density lipoprotein (LDL), and total cholesterol. It inhibits lipid peroxidation, preserves lipid integrity, and affects enzymes involved in lipid metabolism, such as Hydroxymethylglutaryl-CoA (HMG-CoA) reductase and lipoprotein lipase. Additionally, ferulic acid's anti-inflammatory effects help prevent atherosclerosis by reducing arterial inflammation.
OBJECTIVE: To investigate the effects of ferulic acid on lipid metabolism and atherosclerotic index and to compare the effects with a standard lipid-lowering drug (Rosuvastatin).
METHODOLOGY: An experimental study at Khyber Girls’ Medical College (June 20 - July 15, 2024) involved 24 male BALB/c mice, divided into four groups. Groups III and IV received high-fat diets plus ferulic acid and rosuvastatin respectively. Lipid levels were measured after 42 days. Data were analyzed using SPSS and ANOVA with a significance level of p < 0.05.
RESULTS: Group 1 (negative control) had normal lipid levels and Atherosclerotic index. Group 2 (high-fat diet) showed increased lipid levels and AI, with weight gain and lethargy. Group 3 (ferulic acid) and Group 4 (rosuvastatin) maintained healthy lipid levels and Atherosclerotic index (AI). ANOVA revealed significant efficacy (p < 0.001) for both treatments in lowering Triglycerides (TG), Total cholesterol (TC), LDL, and AI, and increasing High-density lipoprotein (HDL).
CONCLUSION: Both ferulic acid and rosuvastatin significantly improved lipid profiles and reduced the atherosclerotic index in mice on a high-fat diet, normalizing TG, TC, LDL, and HDL levels, with highly significant efficacy (p < 0.0001).
KEYWORDS: Ferulic Acid, Lipid homeostasis, Atherosclerotic index
References
Kumar N, Goel N. Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnol Rep (Amst). 2019 Aug 20;24:e00370. Available from https://doi.org/10.1016/j.btre.2019.e00370
Bumrungpert A, Lilitchan S, Tuntipopipat S, Tirawanchai N, Komindr S. Ferulic acid supplementation improves lipid profiles, oxidative stress, and inflammatory status in hyperlipidemic subjects: A randomized, double-blind, placebo-controlled clinical trial. Nutrients. 2018 Jun 2;10(6):713. Available from https://doi.org/10.3390/nu10060713
Paiva LB, Goldbeck R, Santos WD, Squina FM. Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field. Braz. J. Pharm. Sci. 2013;49:395-411. Available from https://doi.org/10.1590/S1984-82502013000300002.
Sangeethadevi G, V V SU, Jansy Isabella RAR, Saravanan G, Ponmurugan P, Chandrasekaran P, Sengottuvelu S, Vadivukkarasi S. Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin-A in isoproterenol-induced myocardial infarction in rats. Drug Chem Toxicol. 2022 Sep;45(5):1951-1962. Available from https://doi.org/10.1080/01480545.2021.1894707.
Gu Y, Zhang Y, Li M, Huang Z, Jiang J, Chen Y, Chen J, Jia Y, Zhang L, Zhou F. Ferulic Acid Ameliorates Atherosclerotic Injury by Modulating Gut Microbiota and Lipid Metabolism. Front Pharmacol. 2021 Mar 25;12:621339. Available from https://doi.org/10.3389/fphar.2021.621339
Zhang XX, Zhao DS, Wang J, Zhou H, Wang L, Mao JL, He JX. The treatment of cardiovascular diseases: a review of ferulic acid and its derivatives. Pharmazie. 2021 Feb 25;76(2):55-60. Available from https://doi.org/10.1691/ph.2021.0958
Pankaj, G., Sanjay, J. Isolation, characterization, and hypolipidemic activity of ferulic acid in high fat-diet induced hyperlipidemia in laboratory rats. EXCLI. J., 2016; 599-613. Available fromhttps://doi.org/10.17179/excli2016-394
Ye L, Hu P, Feng LP, Huang LL, Wang Y, Yan X, Xiong J, Xia HL. Protective effects of ferulic acid on metabolic syndrome: A comprehensive review. Molecules. 2022 Dec 29;28(1):281. Available from https://doi.org/10.3390/molecules28010281
Zhang XX, Zhao DS, Wang J, Zhou H, Wang L, Mao JL, He JX. The treatment of cardiovascular diseases: a review of ferulic acid and its derivatives. Pharmazie. 2021 Feb 25;76(2):55-60. Available from https://doi.org/10.1691/ph.2021.0958
Neto-Neves EM, da Silva Maia Bezerra Filho C, Dejani NN, de Sousa DP. Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential. Mini Rev Med Chem. 2021;21(13):16251637. Available from https://doi.org/10.2174/1389557521666210105122841
Wang J, Tang M, Xie X, Xu Y, Su P, Jin Z. Efficacy of ferulic acid in the treatment of acute ischemic stroke injury in rats: a systematic review and meta-analysis. Front Pharmacol. 2023 Oct 19;14:1278036. Available from https://doi.org/10.3389/fphar.2023.1278036
Nawaboot, J., Piyabhan, P., Munkong, N., Parklak, W., Pannangpetch, P. Ferulic acid improves lipid and glucose homeostasis in high-fat- diet-induced obese mice. Clin Exp Pharma Col. 2016; 43: 242-250. Available from https://doi.org/10.1111/1440-1681.12514
Bumrungpert A, Lilitchan S, Tuntipopipat S, Tirawanchai N, Komindr S. Ferulic acid supplementation improves lipid profiles, oxidative stress, and inflammatory status in hyperlipidemic subjects: A randomized, double-blind, placebo-controlled clinical trial. Nutrients. 2018 Jun 2;10(6):713. https://doi.org/10.3390/nu10060713
Ghosh, S.; Basak, P.; Dutta, S.; Chowdhury, S.; Sil, P.C. New insights into the ameliorative effects of ferulic acid in pathophysiological conditions. Food Chem. Toxicol. 2017, 103, 41–55. Available from https://doi.org/10.1016/j.fct.2017.02.028
Bhaskaragoud, G.; Rajath, S.; Mahendra, V.; Kumar, G.S.; Krishna, A.G.; Kumar, G.S. Hypolipidemic mechanism of oryzanol components-ferulic acid and phytosterols. Biochem. Biophys. Res. Commun. 2016, 476, 82–89. Available from https://doi.org/10.1016/j.bbrc.2016.05.053
Sun P, Zhao L, Zhang N, Zhou J, Zhang L, Wu W, Ji B, Zhou F. Bioactivity of dietary polyphenols: The role in LDL-C lowering. Foods. 2021 Nov 2;10(11):2666. Available from https://doi.org/10.3390/foods10112666
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